- Treatment： 如发生过量，应采取基本措施确保气道通畅，并监测心血管和呼吸系统。通常，停用替扎尼定并给予适当治疗后，症状会在一到三天内缓解。由于作用机制相似，替扎尼定过量的症状和管理与可乐定过量后的症状和管理相似。(L1712)
- exposure pathway： 口服
- Harmful effect： * 用于BRAF突变阳性恶性肿瘤的维莫非尼是CYP1A2抑制剂，可增加替扎尼定的血浆浓度，导致潜在毒性。
- Toxicity summary： 替扎尼定通过在α2-肾上腺素受体位点发挥激动剂作用，增加运动神经元的前突触抑制，从而减少痉挛。
- Regulatory information： REACH注册物质：状态：活跃 更新：22-01-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/21940
- Health Effects： 可能引起潜在危险的皮疹，可能发展为史蒂文斯-约翰逊综合征，这是一种极其罕见但可能致命的皮肤疾病。
- Hepatotoxicity： 可能性评分：C(可能是临床上明显的肝损伤的罕见原因)。
- Hazard categories and classifications： 代表物2 (66.7%)
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation： ◉ 对哺乳和母乳的影响
Warm reminder：
Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！
Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.
Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！
Research chemical CAS 51322-75-9 ≥96% 100mg
Yuanye Research chemical CAS 51322-75-9 ≥96% 100mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
