Xanomeline (LY 246708) is the potent agonist of muscarinic M1/M4 receptor with antipsychotic-like activity. Xanomeline (LY 246708) increases neuronal excitability. Xanomeline (LY 246708) can be used for the research of schizophrenia In Vitro Xanomeline (LY 246708) (0.1-10 μM; CNS4U) shows an overall increase in the mean firing rate. Xanomeline (LY 246708) shows the M1 receptor is functional in hiPSC derived neurons. Xanomeline (LY 246708) (＞1 μM) has a prolonged engagement with the receptor and produces a persistent receptor activation leading to a sustained suppression of the M-current. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Xanomeline (LY 246708) (0.5-3 mg/kg; s.c.; 1-3 hours) induces salivation and vomiting in some monkeys. Xanomeline (LY 246708) shows functional dopamine antagonism and an antipsychotic-like profile. Xanomeline (LY 246708) inhibits D-amphetamine- and (−)-apomorphine-induced behavior and do not cause extrapyramidal side effects. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Cebus apella monkeysDosage: 0.5-3 mg/kg Administration: s.c.; 1-3 hours Result: Induced salivation and vomiting in some monkeys. Form:Solid IC50& Target:M1/M4