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Product introduction
AST 1306是EGFR和HER2的新型抑制剂,IC50分别为0.5 nM和3 nM。 表皮生长因子受体(EGFR)是一种细胞表面受体酪氨酸激酶。受体活化导致二聚化和酪氨酸自磷酸化。它诱导一系列下游细胞应答级联反应,如基因表达修饰、细胞增殖和细胞骨架重排等。HER2是表皮生长因子的一员,与乳腺癌和卵巢癌有关。 在无细胞实验中,AST1306选择性阻断EGFR和HER2激酶的活性。在完整的细胞和无细胞实验中,AST1306可以抑制EGFR突变T790M/L858R的酪氨酸激酶活性。此外,AST1306减弱EGFR和HER2的磷酸化和下游底物。 在ErbB2过表达的异种移植小鼠模型和FVB-2/Nneu转基因小鼠模型中,AST1306有效抑制肿瘤生长。在SK-OV-3异种移植模型中,AST1306对EGFR和HER2产生了快速和长效的抑制,大于等于24h。
Chinese name
艾力替尼, 表皮生长因子受体抑制剂
English name
AST-1306
Chinese alias
-
English alias
ALL-3 | MANDELIC-2,3,4,5,6-D5 ACID | SB19364 | SR-01000076076-1 | XKB38362 | 4-hydroxy-3-methoxyphenylglycolic acid | AC-32040 | CHEBI:91467 | N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)acrylamide | n-(4-((3-chloro-4-((3-fluorophe
CAS number
897383-62-9
molecular formula
C24H18ClFN4O2
molecular weight
448.88 g/mol
Exact mass
-
PSA
76.100 Ų
Logp
5.4
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AST-1306 98% 1mg

Yuanye AST-1306 98% 1mg, CAS 897383-62-9, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:Y45251-1mg
Product model:1mg
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Lead Time:30days
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